Jessica Lönn-Stensrud

• Wiedmer, David; Petersen, Fernanda Cristina; Lönn-Stensrud, Jessica & Tiainen, Hanna (2017). Antibacterial effect of hydrogen peroxide - titanium dioxide suspensions in the decontamination of rough titanium surfaces. Biofouling (Print).  ISSN 0892-7014.  33(6), s 451- 459 . doi: 10.1080/08927014.2017.1322585 Full text in Research Archive.
• Dragland, Inger Sofie; Rukke, Håkon Valen; Stenhagen, Ida Sofia Refsholt; Lönn-Stensrud, Jessica & Kopperud, Hilde Beate M. (2016). Antibacterial and Antibiofilm Effect of Low Viscosity Chitosan against Staphylococcus epidermidis. International Journal of Microbiology.  ISSN 1687-918X.  2016:9159761 . doi: 10.1155/2016/9159761 Show summary

  Aim The aim of this study was to investigate the antibacterial and antibiofilm properties of low viscosity chitosan on S. epidermidis growth and biofilm formation. Methods and Results The antibacterial and antibiofilm properties were investigated, during both planktonic growth and biofilm formation. This was performed using different concentrations in media and by coating on polystyrene surfaces. In addition, the bactericidal effect was investigated using a modified direct contact test. The results showed that low viscosity chitosan in media had both a bacteriostatic and bactericidal effect on planktonic growth and biofilm formation of S. epidermidis in a concentration dependent manner. Polystyrene discs coated with chitosan reduced both early biofilm formation (6 h) and late biofilm formation (18 h), as confirmed by scanning electron microscopy. The modified direct contact test showed a bactericidal effect. Conclusion This study demonstrated that low viscosity chitosan has a bacteriostatic and bactericidal activity against S. epidermidis and that the activity is dependent on the amount of chitosan added. In addition, low viscosity chitosan reduced biofilm formation both when added to media and when coated on polystyrene surfaces. Significance and Impact of Study Low viscosity chitosan could be a contribution to new treatment approaches of biofilm-related infections of S. epidermidis.

• Xing, Rui; Witsø, Ingun Lund; Jugowiec, David; Tiainen, Hanna; Shabestari, Maziar; Lyngstadaas, Ståle Petter; Lönn-Stensrud, Jessica & Haugen, Håvard Jostein (2015). Antibacterial effect of doxycycline-coated dental abutment surfaces. Biomedical Materials.  ISSN 1748-6041.  10(5), s 55003- 55012 . doi: 10.1088/1748-6041/10/5/055003 Show summary

  Biofilm formation on dental abutment may lead to peri-implant mucositis and subsequent peri-implantitis. These cases are clinically treated with antibiotics such as doxycycline (Doxy). Here we used an electrochemical method of cathodic polarization to coat Doxy onto the outer surface of a dental abutment material. The Doxy-coated surface showed a burst release in phosphate-buffered saline during the first 24 h. However, a significant amount of Doxy remained on the surface for at least 2 weeks especially on a 5 mA–3 h sample with a higher Doxy amount, suggesting both an initial and a long-term bacteriostatic potential of the coated surface. Surface chemistry was analyzed by x-ray photoelectron spectroscopy and secondary ion mass spectrometry. Surface topography was evaluated by field emission scanning electron microscopy and blue-light profilometry. Longer polarization time from 1 h to 5 h and higher current density from 1 to 15 mA cm−2 resulted in a higher amount of Doxy on the surface. The surface was covered by a layer of Doxy less than 100 nm without significant changes in surface topography. The antibacterial property of the Doxy-coated surface was analyzed by biofilm and planktonic growth assays using Staphylococcus epidermidis. Doxy-coated samples reduced both biofilm accumulation and planktonic growth in broth culture, and also inhibited bacterial growth on agar plates. The antibacterial effect was stronger for samples of 5 mA–3 h coated with a higher amount of Doxy compared to that of 1 mA–1 h. Accordingly, an abutment surface coated with Doxy has potential for preventing bacterial colonization when exposed to the oral cavity. Doxy-coating could be a viable way to control peri-implant mucositis and prevent its progression into peri-implantitis.

• Gustumhaugen, Eva; Lönn-Stensrud, Jessica; Scheie, Anne Aamdal; Lyngstadaas, Ståle Petter; Ekfeldt, Anders & Taxt-Lamolle, Sebastien Francis Michel (2014). Effect of chemical and mechanical debridement techniques on bacterial re-growth on rough titanium surfaces: an in vitro study. Clinical Oral Implants Research.  ISSN 0905-7161.  25(6), s 707- 713 . doi: 10.1111/clr.12130 Show summary

  Objective The aim of this in vitro study was to compare the effect of combined chemical and mechanical debridement of titanium (Ti) surfaces inoculated with Staphylococcus epidermidis, compared with the effect of chemical debridement alone. Material and Methods Different Ti surfaces were characterized with respect to roughness and subsequently inoculated with S. epidermidis. NaCl (0.9 vol.%), EDTA (12 vol.%), H2O2 (3 vol.%) or H2O2 + TiO2 nanoparticles served as chemical debridement agents, while TiBrush™ was used as the mechanical debridement tool. Safranin staining assessed biomass still attached to surfaces after debridement. Biofilm viability was assessed after re-incubation of the debrided samples. SEM analysis was performed before and after the cleaning process. Results Surface average roughness (Sa) of the samples was measured at 2.22 ± 0.19 μm for group A, 0.19 ± 0.02 μm for group B, and 1.99 ± 0.10 μm for group C. When chemical debridement agents were used alone, H2O2-containing products were most efficient in reducing the biomass load. The surface roughness did not affect the outcome of chemical debridement. However, when combining chemical and mechanical debridement, a further reduction of biofilm load and viability was observed with best effect on the smoothest surface. Conclusions Combining H2O2-containing chemical agents with mechanical debridement (TiBrush™) provided best reduction in biofilm mass and re-growth, when studied in vitro.

• Westas, Emma Carolina A. A.; Gillstedt, Martin; Lönn-Stensrud, Jessica; Bruzell, Ellen & Andersson, Martin (2014). Biofilm formation on nanostructured hydroxyapatite-coated titanium. Journal of Biomedical Materials Research. Part A.  ISSN 1549-3296.  102(4), s 1063- 1070 . doi: 10.1002/jbm.a.34757 Show summary

  Biofilm formation on medical devices is a common cause of implant failure, especially regarding implants that breach the epithelial tissue, so-called transcutaneous implants. Nanotechnology and the development of new nanomaterials have given the opportunity to design nanotextured implant surfaces. Such surfaces have been studied using various in vitro methods showing that nanosized features strongly benefit bone cell growth. However, little is known on how nanostructured features affect biofilm formation. The aim of this study was therefore to examine the shape- and chemical-dependent effect of a nanostructured hydroxyapatite (HA) coating on the degree of Staphylococcus epidermidis biofilm formation. Three different types of nanosized HA particles having different shapes and calcium to phosphate ratios were compared to uncoated turned titanium using safranin stain in a biofilm assay and confocal laser scanning microscopy (CLSM) for assessment of biofilm biomass and bacterial volume, respectively. No difference in biofilm biomass was detected for the various surfaces after 6 h incubation with S. epidermidis. Additionally, image analysis of CLSM Z-stacks confirmed the biofilm assay and showed similar results. In conclusion, the difference in nanomorphology and chemical composition of the surface coatings did not influence the adhesion and biofilm formation of S. epidermidis. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

• Witsø, Ingun Lund; Benneche, Tore; Vestby, Lene Karine; Nesse, Live Lingaas; Lönn-Stensrud, Jessica & Scheie, Anne Aamdal (2014). Thiophenone and Furanone in Control of Escherichia coli O103:H2 Virulence. Pathogens and Disease.  ISSN 2049-632X.  70(3), s 297- 306 . doi: 10.1111/2049-632X.12128
• Lönn-Stensrud, Jessica; Benneche, Tore & Scheie, Anne Aamdal (2012). Kan bakteriers kommunikation öppna för nya infektionsbehandlingar?. Läkartidningen.  ISSN 0023-7205.  (9)
• Lönn-Stensrud, Jessica; Naemi, Ali-Oddin; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2012). Thiophenones inhibit Staphylococcus epidermidis biofilm formation at nontoxic concentrations. FEMS Immunology and Medical Microbiology.  ISSN 0928-8244.  65(2), s 326- 334 . doi: 10.1111/j.1574-695X.2012.00964.x
• Lönn-Stensrud, Jessica; Benneche, Tore & Scheie, Anne Aamdal (2011). Furanones and Thiophenones in Control of Staphylococcus epidermidis Biofilm Infections?, In Antonio Mendez-Vilas (ed.),  Science and Technology against Microbial Pathogens. Research, Development and Evaluation.  World Scientific.  ISBN 978-981-4354-85-1.  Antimicrobial Surfaces. Biofilms. Quorum Sensing. Consumer Products.  s 155 - 159
• Vestby, Lene Karine; Lönn-Stensrud, Jessica; Møretrø, Trond; Langsrud, Solveig; Scheie, Anne Aamdal; Benneche, Tore & Nesse, Live Lingaas (2010). A synthetic furanone potentiates the effect of disinfectants on Salmonella in biofilm. Journal of Applied Microbiology.  ISSN 1364-5072.  108(3), s 771- 778 . doi: 10.1111/j.1365-2672.2009.04495.x
• Lönn-Stensrud, Jessica; Landin, Maria Augusta Dos S Silva; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2009). Furanones, potential agents for preventing Staphylococcus epidermidis biofilm infections?. Journal of Antimicrobial Chemotherapy.  ISSN 0305-7453.  63(2), s 309- 316 . doi: 10.1093/jac/dkn501
• Benneche, Tore; Hussain, Zainab; Scheie, Anne Aamdal & Lönn-Stensrud, Jessica (2008). Synthesis of 5-(bromomethylene)furan-2(5H)-ones and 3-(bromomethylene)isobenzofuran-1(3H)-ones as inhibitors of microbial quorum sensing. New Journal of Chemistry.  ISSN 1144-0546.  32(9), s 1567- 1572 . doi: 10.1039/b803926g
• Lönn-Stensrud, Jessica; Petersen, Fernanda Cristina; Benneche, Tore & Scheie, Anne Aamdal (2007). Synthetic bromated furanone inhibits autoinducer-2-mediated communication and biofilm formation in oral streptococci. Oral Microbiology and Immunology.  ISSN 0902-0055.  22, s 340- 346
• Benneche, Tore; Lønn-Stensrud, Anna Maria Jessica & Scheie, Anne Aamdal (2006). Synthesis of (E)- and (Z)-5-(bromomethylene)furan-2(5H)-one by bromodecarboxylation of (E)-2-(5-oxofuran-2(5H)-ylidene)acetic acid. Synthetic Communications.  ISSN 0039-7911.  36

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• Lönn-Stensrud, Jessica (2016). Bakterienes forunderlige verden. Universitetsforlaget.  ISBN 9788215024967.  176 s.

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• Jemterud, Torkild; Samset, Bjørn Hallvard; Lönn-Stensrud, Jessica & Røyne, Anja (2017, 24. november). Abels Tårn, NRK P2: "Kan månen ha noe å si når naturkatastrofer på jorda blir utløst? Har du opplevd at eggerøra i matavfallet har begynt å lyse? Har brus med CO2 noen innvirkning på klimaet?". [Radio].  NRK P2.
• Lönn-Stensrud, Jessica (2017). Bakterier og antibiotikaresistens.
• Lönn-Stensrud, Jessica (2017, 16. oktober). Deltakelse på Ekko P2. [Radio].  NRK, Marienlyst, Oslo.
• Lönn-Stensrud, Jessica (2017). Sjokolade og bakterier hører sammen. Dagbladet.no.
• Lönn-Stensrud, Jessica (2016). Antibiotikaresistens - Den stille pandemien.
• Lönn-Stensrud, Jessica (2016). Antibiotikaresistens - trussel og håp.
• Lönn-Stensrud, Jessica (2016). Kampen om overflaten. Naturfag : tidsskrift for Nasjonalt nettverk for naturfag.  ISSN 1501-8601.  1, s 58- 60
• Sturød, Kjersti; Scheie, Anne Aamdal; Rukke, Håkon Valen & Lönn-Stensrud, Jessica (2016). Skjebnesvangre reiser - ingen vei tilbake?.
• Wiedmer, David; Tiainen, Hanna; Lönn-Stensrud, Jessica; Petersen, Fernanda Cristina & Haugen, Håvard Jostein (2016). TiO2-H2O2 as decontamination agent - an in vitro study.
• Austrheim, Gunhild; Gullbekk, Eystein & Lönn-Stensrud, Jessica (2015). PhD on Track: på reise med brukerne.
• Lönn-Stensrud, Jessica (2015). Antibiotikaresistens - den stille pandemien.
• Lönn-Stensrud, Jessica (2015). Antibiotikaresistens - er mirakelmedisinens ære over?.
• Lönn-Stensrud, Jessica (2015). Antibiotikaresistens - trussel og håp.
• Lönn-Stensrud, Jessica (2015). Antibiotikaresistens - trussel og håp.
• Lönn-Stensrud, Jessica (2015). En lommelykt i havet. Naturfag : tidsskrift for Nasjonalt nettverk for naturfag.  ISSN 1501-8601.  2, s 66- 67
• Lönn-Stensrud, Jessica (2015). Noen av oss må bruke mindre antibiotika. Aftenposten Viten.
• Witsø, Ingun Lund; Scheie, Anne Aamdal & Lönn-Stensrud, Jessica (2015). Quorum sensing interferes with bacterial virulence.
• Lönn-Stensrud, Jessica (2014). Etter mirakelmedisinen. Aftenposten Viten.
• Lönn-Stensrud, Jessica (2014). Norden må lede an i kampen mot antibiotikaresistens.. Aftenposten Viten.
• Lönn-Stensrud, Jessica (2014). Small talk. Cell-to-cell communication in bacteria.
• Lönn-Stensrud, Jessica (2014). Veien til ny mirakelmedisin. Aftenposten Viten.
• Lönn-Stensrud, Jessica & Gullbekk, Eystein (2014). PhD on track – working with generic skills in context.
• Lundmark, Anders Mattias & Lönn-Stensrud, Jessica (2014). Launching high school teaching support at the University of Oslo Science Library.
• Witsø, Ingun Lund; Rukke, Håkon Valen; Assev, Synnøve; Benneche, Tore; Lönn-Stensrud, Jessica & Scheie, Anne Aamdal (2014). Structure-activity relationships in thiophenone.
• Gustumhaugen, Eva; Lönn-Stensrud, Jessica; Scheie, Anne Aamdal; Lyngstadaas, Ståle Petter & Taxt-Lamolle, Sebastien Francis Michel (2012). Chemical and Mechanical Debridement of Rough Titanium Surfaces in vitro.
• Witsö, I.L.; Benneche, Tore; Nesse, Live L.; Vestby, Lene Karine; Lönn-Stensrud, Jessica & Scheie, Anne Aamdal (2012). Thiophenone TF101 in control of E. coli biofilm?.
• Lönn-Stensrud, Jessica (2011). Synthetic furanones and inhibition of biofilm formation.
• Lönn-Stensrud, Jessica; Naemi, Ali-Oddin; Assev, Synnøve; Benneche, Tore & Scheie, Anne Aamdal (2011). New synthetic thiophenones inhibit biofilm formation by S. epidermidis.
• Lönn-Stensrud, Jessica (2010). Furanones and thiophenones in control of S. epidermidis biofilm infections?.
• Lönn-Stensrud, Jessica (2010). Furanones, potential agents for preventing Staphylococcus epidermidis biofilm infections?.
• Lönn-Stensrud, Jessica; Benneche, Tore & Scheie, Anne Aamdal (2010). Furanones and thiophenones in control of S. epidermidis biofilm infections?.
• Vestby, Lene Karine; Møretrø, Trond; Ballance, Simon; Benneche, Tore; Scheie, Anne Aamdal; Lönn-Stensrud, Jessica; Heir, Even & Nesse, Live Lingaas (2010). Persistence and eradication of Salmonella from the feed environment.
• Lönn-Stensrud, Jessica (2009). Synthetic furanones and inhibition of biofilm formation. Full text in Research Archive.
• Vestby, Lene K.; Lönn-Stensrud, Jessica; Møretrø, Trond; Langsrud, Solveig; Scheie, Anne Aamdal; Benneche, Tore & Nesse, Live (2009). The effect of a synthetic furanone and disinfectants on Salmonella in biofilm.
• Vestby, Lene K.; Lönn-Stensrud, Jessica; Møretrø, Trond; Langsrud, Solveig; Scheie, Anne Aamdal; Benneche, Tore & Nesse, Live (2009). The effect of a synthetic furanone and disinfectants on Salmonella in biofilm.
• Vestby, Lene Karine; Lönn-Stensrud, Jessica; Møretrø, Trond; Langsrud, Solveig; Scheie, Anne Aamdal; Benneche, Tore & Nesse, Live Lingaas (2009). The effect of a synthetic furanone and disinfectants on Salmonella in biofilm.
• Vestby, Lene Karine; Lönn-Stensrud, Jessica; Møretrø, Trond; Langsrud, Solveig; Scheie, Anne Aamdal; Benneche, Tore & Nesse, Live Lingaas (2009). The effect of a synthetic furanone and disinfectants on Salmonella in biofilm.
• Lönn-Stensrud, Jessica (2008). Furanones: tools for controlling biofilm infections.
• Nesse, Live; Vestby, Lene K.; Lönn-Stensrud, Jessica; Petersen, Fernanda Cristina; Møretrø, Trond; Langsrud, Solveig; Benneche, Tore & Scheie, Anne Aamdal (2008). The effect of a synthetic bromated furanone on the production of biofilm by different Salmonella wild type strains.
• Vestby, Lene Karine; Nesse, Live Lingaas; Lönn-Stensrud, Jessica; Petersen, Fernanda Cristina; Møretrø, Trond; Langsrud, Solveig; Benneche, Tore & Scheie, Anne Aamdal (2008). AI-2 production by different wild-type Salmonella strains and the effect of biofilm formation by introducing AHL, GMP and a synthetic bromated furanones.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). AI-2 Mediated Biofilm Formation in Oral Streptococci is Inhibited by Bromated Furanone.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). AI-2 Mediated Biofilm Formation in Oral Streptococci is Inhibited by Bromated Furanone.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Bakterier snakker, vi lider. Aftenposten (morgenutg. : trykt utg.).  ISSN 0804-3116.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Bakteriesnakk gir tanntrøbbel. Forskning.no : nettavis med nyheter fra norsk og internasjonal forskning.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Biofilm formation in Staphylococcus epidermidis is Inhibited by Synthetic Brominated Furanones. Show summary

  The coagulase-negative staphylococci (CNS) are commensals of human skin and mucous membranes. Staphylococcus epidermidis is the most frequently isolated CNS species, and also one of the major nosocomial pathogens associated with infections on medical implants. The cause of infections is primarily related to biofilm formation on the implant. S. epidermidis infections represent a major burden to the public health system, and are often responsible for prolonged hospitalisation and occasional deaths. Microorganisms in nature prefer a biofilm life style. Biofilm infections are often difficult to treat due to increased resistance both to antibiotics and to the immune system. The algae Delisea pulchra produces bromated furanones that prevent bacterial biofilm formation on its surface. Similar furanones may interfere with both autoinducer-2 and autoinducer-1 signalling in Gram-positive and Gram-negative microorganisms without affecting bacterial growth.

• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Biofilm formation in Staphylococcus epidermidis is inhibited by synthetic bromated furanones.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Furanones Inhibit AI-2 Mediated Communication in Bacteria at Non-Irritant Concentrations.
• Vestby, Lene K.; Lönn-Stensrud, Jessica; Petersen, Fernanda Cristina; Scheie, Anne Aamdal; Møretrø, Trond; Langsrud, Solveig & Nesse, Live (2007). The role of autoinducer-2 in biofilm formaion by salmonella.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2006). AI-2 Mediated Communication in Streptococcus anginosus, Streptococcus intermedius and Streptococcus mutans is Inhibited by Bromated Furanone.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2006). AI-2 Mediated Biofilm Formation in Oral Streptococci is Inhibited by Bromated Furanone.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2006). AI-2 Mediated Communication in Oral Streptococci is Inhibited by Bromated Furanone.
• Nesse, Live; Vestby, Lene K.; Lönn-Stensrud, Jessica; Møretrø, Trond; Langsrud, Solveig; Scheie, Anne Aamdal; Petersen, Fernanda Cristina & Heir, Even (2006). PRODUCTION OF BIOFILM AND AI-2 IN SALMONELLA STRAINS FROM DIFFERENT SOURCES.

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